Amifampridine phosphate myasthenia gravis

Jan 1 20A CT scan showing a thymoma, often associated with myasthenia gravis. Firdapse (Amifampridine) - Myasthenia Gravis News Jan 1 20Amifampridine Phosphate, an investigational agent for treating patients with MuSK antibody positive myasthenia gravis, has shown success in clinical study. METHODS : This phase randomize double-blin placebo-controlled withdrawal trial in adults with LEMS compared efficacy of amifampridine phosphate versus placebo over a 4-day period.

Amifampridine phosphate, under development by Catalyst Pharmaceuticals, is a potassium channel inhibitor designed to prolong signals released from nerves and allow greater stimulation of muscles. Amifampridine - m Amifampridine has been granted orphan drug designation by the FDA for the treatment of patients with congenital myasthenic syndromes (CMS) and MuSK-positive myasthenia gravis (MuSK-MG). There is an ongoing investigational program for amifampridine in the treatment of.

Despite positive data observed with Catalyst Pharmaceuticals Firdapse (amifampridine phosphate) in a proof-of-concept (POC) investigator-sponsored trial in muscle-specific tyrosine kinase myasthenia gravis (MuSK-MG the clinical relevance is hard to determine). Trial to Test Firdapse in MG Seeks Participants - Muscular. The drug currently is under clinical investigation as a symptomatic therapy to treat muscle weakness in people with MuSK-antibody positive myasthenia gravis.

Study to Evaluate Amifampridine Phosphate in Patients With

The MuSK antibody positive myasthenia gravis treatment met both co-primary end points as well as a number of secondary end points, showing promise despite a small sample size. Oct 0 20A Randomize Placebo-control, Parallel Group Study to Evaluate the Effect of Amifampridine Phosphate in Patients With MuSK Antibody Positive Myasthenia Gravis, and a Sample of AChR Antibody Positive Myasthenia Gravis Patients: Actual Study Start Date : March 2018: Actual Primary Completion Date : January 3 2020: Estimated Study Completion Date. The primary endpoints were quantitative myasthenia gravis score (QMG) and subject global impression, and the secondary endpoint was Clinical Global Impression-Improvement.

Feb 2 20The primary objectives of the study were to assess the clinical efficacy of amifampridine phosphate compared with placebo in patients with LEMS based on improvement in subject global impression (SGI) and quantitative myasthenia gravis (QMG) score, and to confirm the tolerability of amifampridine phosphate by adverse event (AE) reports.
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